CD1b est un gène codé par le symbole CD1B. Il est également connu sous le nom de T-cell surface glycoprotein CD1B. CD1b a une masse de 36.94kDa et une longueur d'acide aminé de 333.
Nous proposons 13 des anticorps contre CD1b, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Résumé Entrez
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens.
Spécificité tissulaire
Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
Localisation cellulaire
Cell membrane. Endosome membrane. Lysosome membrane.
Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes.
