CD161 est un gène codé par le symbole KLRB1. D'autres noms incluent: Killer cell lectin-like receptor subfamily B member 1; C-type lectin domain family 5 member B; HNKR-P1a; NKR-P1A; Natural killer cell surface protein P1A; KLRB1; CLEC5B; NKRP1A. CD161 a une masse de 25.42kDa et une longueur d'acide aminé de 225.
Nous proposons 22 des anticorps contre CD161, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, Cytométrie en Flux, IP et RIA avec des échantillons dérivés de Humain, Souris, Rat et Primates.
Informations sur les Gènes et les Protéines
Résumé UniProt
Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Résumé Entrez
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus.
Spécificité tissulaire
Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
Modification post-traductionnelle
N-glycosylated. Contains sialic acid residues.
Localisation cellulaire
Membrane.
