CD153 est un gène codé par le symbole TNFSF8. D'autres noms incluent: Tumor necrosis factor ligand superfamily member 8; CD30 ligand; CD30-L; TNFSF8; CD30L; CD30LG. CD153 a une masse de 26.02kDa et une longueur d'acide aminé de 234.
Nous proposons 7 des anticorps contre CD153, élevé dans Lapin, qui sont appropriés pour le WB, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.
Résumé Entrez
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
Similitudes de séquence
Belongs to the tumor necrosis factor family.
Localisation cellulaire
Membrane.
