Anticorps CBL

13 produits

CBL est un gène codé par le symbole CBL. D'autres noms incluent: E3 ubiquitin-protein ligase Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-RING finger protein 55; RING-type E3 ubiquitin transferase Signal transduction protein CBL2; RNF55. CBL a une masse de 99.63kDa, une longueur d'acide aminé de 906, et est impliqué dans Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia.

Nous proposons 13 des anticorps contre CBL, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.

Informations sur les Gènes et les Protéines

Résumé UniProt
Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity).
Résumé Entrez
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
Implication dans la maladie
Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia: A syndrome characterized by a phenotype reminiscent of Noonan syndrome. Clinical features are highly variable, including facial dysmorphism, short neck, developmental delay, hyperextensible joints and thorax abnormalities with widely spaced nipples. The facial features consist of triangular face with hypertelorism, large low-set ears, ptosis, and flat nasal bridge. Some patients manifest cardiac defects. Some have an increased risk for certain malignancies, particularly juvenile myelomonocytic leukemia.
Modification post-traductionnelle
Phosphorylated on tyrosine residues by ALK, EGFR, SYK, FYN and ZAP70 (By similarity). Phosphorylated on tyrosine residues in response to FLT1 and KIT signaling. Phosphorylated on tyrosine residues by INSR and FGR. Phosphorylated on several tyrosine residues by constitutively activated FGFR3. Not phosphorylated at Tyr-731 by FGFR3. Phosphorylated on tyrosine residues by activated CSF1R, PDGFRA and PDGFRB. Phosphorylated on tyrosine residues by HCK.
Localisation cellulaire
Cytoplasm. Cell membrane. Cell projection > Cilium. Golgi apparatus.

Colocalizes with FGFR2 in lipid rafts at the cell membrane.
Western Blot - Anti-CBL Antibody (A87609) - Antibodies.com
(8)
Western Blot - Anti-CBL Antibody (A15951) - Antibodies.com
(4)
Western Blot - Anti-CBL Antibody (A83807) - Antibodies.com
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Western Blot - Anti-CBL (phospho Tyr700) Antibody (A88028) - Antibodies.com
Western Blot - Anti-CBL (phospho Tyr774) Antibody (A91808) - Antibodies.com
Anti-Cbl (E768) Antibody from Bioworld Technology (BS1439) - Antibodies.com
(3)
Anti-Cbl (G694) Antibody from Bioworld Technology (BS1519) - Antibodies.com
(2)
Western blot - Cbl Antibody from Signalway Antibody (24466) - Antibodies.com
(2)
Anti-Cbl (phospho-Y700) Antibody from Bioworld Technology (BS4541) - Antibodies.com
Anti-Cbl (S668) Antibody from Bioworld Technology (BS1440) - Antibodies.com
Western blot - CBL (Phospho-Tyr674) Antibody from Signalway Antibody (11946) - Antibodies.com
CBL Antibody from Signalway Antibody (37449) - Antibodies.com

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