Cathepsin K est un gène codé par le symbole CTSK. D'autres noms incluent: Cathepsin O; Cathepsin O2; Cathepsin X; CTSK; CTSO; CTSO2. Cathepsin K a une masse de 36.97kDa, une longueur d'acide aminé de 329, et est impliqué dans Pycnodysostosis.
Nous proposons 10 des anticorps contre Cathepsin K, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042).
Résumé Entrez
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.
Spécificité tissulaire
Predominantly expressed in osteoclasts (bones) (PubMed:7805878). Expressed in thyroid epithelial cells (PubMed:11082042).
Implication dans la maladie
Pycnodysostosis: A rare autosomal recessive bone disorder characterized by deformity of the skull, maxilla and phalanges, osteosclerosis, and fragility of bone.
Similitudes de séquence
Belongs to the peptidase C1 family.
Localisation cellulaire
Lysosome. Secreted. Apical cell membrane.
Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.
