Catalase est un gène codé par le symbole CAT. Il est également connu sous le nom de CAT. Catalase a une masse de 59.76kDa, une longueur d'acide aminé de 527, et est impliqué dans Acatalasemia.
Nous proposons 39 des anticorps contre Catalase, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux, IP et Dot-Blot avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Singe et Canin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
Résumé Entrez
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene.
Implication dans la maladie
Acatalasemia: A metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. Acatalasemia is inherited as an autosomal recessive trait.
Similitudes de séquence
Belongs to the catalase family.
Modification post-traductionnelle
The N-terminus is blocked.
Localisation cellulaire
Peroxisome.
