CAMKK2 est un gène codé par le symbole CAMKK2. D'autres noms incluent: Calcium/calmodulin-dependent protein kinase kinase 2; CaM-KK 2; Calcium/calmodulin-dependent protein kinase kinase beta; CaM-KK beta; CAMKKB; KIAA0787. CAMKK2 a une masse de 64.75kDa et une longueur d'acide aminé de 588.
Nous proposons 6 des anticorps contre CAMKK2, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
Résumé Entrez
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases.
Spécificité tissulaire
Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung.
Similitudes de séquence
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Modification post-traductionnelle
Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation.
Localisation cellulaire
Nucleus. Cytoplasm. Cell projection > Neuron projection.
Predominantly nuclear in unstimulated cells, relocalizes into cytoplasm and neurites after forskolin induction.
