Calpastatin est un gène codé par le symbole CAST. D'autres noms incluent: Calpain inhibitor; Sperm BS-17 component; CAST. Calpastatin a une masse de 76.57kDa, une longueur d'acide aminé de 708, et est impliqué dans Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads.
Nous proposons 6 des anticorps contre Calpastatin, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
Résumé Entrez
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
Implication dans la maladie
Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads: An autosomal recessive disease characterized by generalized, continuous shedding of the outer layers of the epidermis, leukonychia, acral punctate keratosis, cheilitis, knuckle pads with multiple hyperkeratotic micropapules involving the interphalangeal joints, and palmoplantar keratoderma.
Similitudes de séquence
Belongs to the protease inhibitor I27 (calpastatin) family.
Modification post-traductionnelle
The N-terminus is blocked.
