Calcipressin 1 est un gène codé par le symbole RCAN1. D'autres noms incluent: Calcipressin-1; Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1; RCAN1; ADAPT78; CSP1; DSC1; DSCR1. Calcipressin 1 a une masse de 28.08kDa et une longueur d'acide aminé de 252.
Nous proposons 7 des anticorps contre Calcipressin 1, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity).
Résumé Entrez
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants.
Spécificité tissulaire
Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.
Similitudes de séquence
Belongs to the RCAN family.
Modification post-traductionnelle
Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.
