Bub3 est un gène codé par le symbole BUB3. Il est également connu sous le nom de Mitotic checkpoint protein BUB3. Bub3 a une masse de 37.16kDa et une longueur d'acide aminé de 328.
Nous proposons 10 des anticorps contre Bub3, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Résumé Entrez
This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Similitudes de séquence
Belongs to the WD repeat BUB3 family.
Modification post-traductionnelle
Poly-ADP-ribosylated by PARP1.
Localisation cellulaire
Nucleus. Chromosome > Centromere > Kinetochore.
Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition.
