BTF est un gène codé par le symbole BCLAF1. D'autres noms incluent: Bcl-2-associated transcription factor 1; BCLAF1 and THRAP3 family member 1; BCLAF1; KIAA0164. BTF a une masse de 106.12kDa et une longueur d'acide aminé de 920.
Nous proposons 7 des anticorps contre BTF, élevé dans Lapin, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
Résumé Entrez
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Ubiquitous.
Similitudes de séquence
Belongs to the BCLAF1/THRAP3 family.
Modification post-traductionnelle
Citrullinated by PADI4.
Localisation cellulaire
Cytoplasm. Nucleus. Nucleus speckle. Nucleus > Nucleoplasm.
