BS69 est un gène codé par le symbole ZMYND11. D'autres noms incluent: Zinc finger MYND domain-containing protein 11; Adenovirus 5 E1A-binding protein; Bone morphogenetic protein receptor-associated molecule 1; Protein ZMYND11; BRAM1. BS69 a une masse de 70.96kDa, une longueur d'acide aminé de 602, et est impliqué dans Mental retardation, autosomal dominant 30.
Nous proposons 6 des anticorps contre BS69, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.
Résumé Entrez
The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified.
Spécificité tissulaire
Ubiquitous.
Implication dans la maladie
Mental retardation, autosomal dominant 30: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD30 patients manifest mild intellectual disability and subtle facial dysmorphisms, including hypertelorism, ptosis, and a wide mouth.
Modification post-traductionnelle
Sumoylated following its interaction with PIAS1 and UBE2I.
Localisation cellulaire
Nucleus. Chromosome.
Associates with chromatin and mitotic chromosomes.
