Blood Group H2 antigen est un gène codé par le symbole ABO. D'autres noms incluent: Histo-blood group ABO system transferase; Fucosylglycoprotein 3-alpha-galactosyltransferase; Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; Glycoprotein-fucosylgalactoside alpha-galactosyltransferase; Histo-blood group A transferase; A transferase; Histo-blood group B transferase; B transferase; NAGAT; ABO. Blood Group H2 antigen a une masse de 40.93kDa et une longueur d'acide aminé de 354.
Nous proposons 10 des anticorps contre Blood Group H2 antigen, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris, Rat et Porcin.
Informations sur les Gènes et les Protéines
Résumé UniProt
This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
Résumé Entrez
This gene encodes proteins related to the first discovered blood group system, ABO. Which allele is present in an individual determines the blood group. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene.
Similitudes de séquence
Belongs to the glycosyltransferase 6 family.
Modification post-traductionnelle
The soluble form derives from the membrane form by proteolytic processing.
Localisation cellulaire
Golgi apparatus > Golgi stack membrane. Secreted.
Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
