Bik est un gène codé par le symbole BIK. D'autres noms incluent: Bcl-2-interacting killer; Apoptosis inducer NBK; BIP1; BP4; NBK. Bik a une masse de 18.02kDa et une longueur d'acide aminé de 160.
Nous proposons 9 des anticorps contre Bik, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.
Résumé Entrez
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins.
Modification post-traductionnelle
Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism.
Localisation cellulaire
Endomembrane system. Mitochondrion membrane.
Around the nuclear envelope, and in cytoplasmic membranes.
