BCMA est un gène codé par le symbole TNFRSF17. D'autres noms incluent: Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; TNFRSF17; BCM. BCMA a une masse de 20.17kDa et une longueur d'acide aminé de 184.
Nous proposons 34 des anticorps contre BCMA, élevé dans Lapin, Souris et Human, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Résumé Entrez
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
Spécificité tissulaire
Expressed in mature B-cells, but not in T-cells or monocytes.
Localisation cellulaire
Cell membrane. Endomembrane system.
Perinuclear Golgi-like structures.
