Bcl2L2 est un gène codé par le symbole BCL2L2. D'autres noms incluent: Bcl-2-like protein 2; Bcl2-L-2; Apoptosis regulator Bcl-W; BCLW; KIAA0271. Bcl2L2 a une masse de 20.75kDa et une longueur d'acide aminé de 193.
Nous proposons 10 des anticorps contre Bcl2L2, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
Résumé Entrez
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
Spécificité tissulaire
Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.
Similitudes de séquence
Belongs to the Bcl-2 family.
Localisation cellulaire
Mitochondrion membrane.
Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.
