BCAT1 est un gène codé par le symbole BCAT1. D'autres noms incluent: Branched-chain-amino-acid aminotransferase, cytosolic; BCAT(c); Protein ECA39; BCT1; ECA39. BCAT1 a une masse de 42.97kDa et une longueur d'acide aminé de 386.
Nous proposons 8 des anticorps contre BCAT1, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris, Rat et Canin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Résumé Entrez
This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described.
Spécificité tissulaire
During embryogenesis, expressed in the brain and kidney. Overexpressed in MYC-induced tumors such as Burkitt's lymphoma.
Similitudes de séquence
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Localisation cellulaire
Cytoplasm.
