BACH1.3 est un gène codé par le symbole BACH1. D'autres noms incluent: Transcription regulator protein BACH1; BTB and CNC homolog 1; HA2303; BACH1. BACH1.3 a une masse de 81.96kDa et une longueur d'acide aminé de 736.
Nous proposons 10 des anticorps contre BACH1.3, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498).
Résumé Entrez
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene.
Similitudes de séquence
Belongs to the bZIP family. CNC subfamily.
Modification post-traductionnelle
Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteasome.
Localisation cellulaire
Nucleus.
