Apolipoprotein L 1 est un gène codé par le symbole APOL1. D'autres noms incluent: Apolipoprotein L1; Apolipoprotein L; Apo-L; Apolipoprotein L-I; ApoL-I; APOL1; APOL. Apolipoprotein L 1 a une masse de 43.97kDa, une longueur d'acide aminé de 398, et est impliqué dans Focal segmental glomerulosclerosis 4.
Nous proposons 7 des anticorps contre Apolipoprotein L 1, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
Résumé Entrez
This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Plasma. Found on APOA-I-containing high density lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, placenta and spleen.
Implication dans la maladie
Focal segmental glomerulosclerosis 4: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
Similitudes de séquence
Belongs to the apolipoprotein L family.
Modification post-traductionnelle
Phosphorylated by FAM20C in the extracellular medium.
Localisation cellulaire
Secreted.
