APOA4 est un gène codé par le symbole APOA4. D'autres noms incluent: Apolipoprotein A-IV; Apo-AIV; Apolipoprotein A4. APOA4 a une masse de 45.4kDa et une longueur d'acide aminé de 396.
Nous proposons 5 des anticorps contre APOA4, élevé dans Lapin et Souris, qui sont appropriés pour le WB et IHC avec des échantillons dérivés de Humain.
Informations sur les Gènes et les Protéines
Résumé UniProt
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
Résumé Entrez
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro.
Spécificité tissulaire
Synthesized primarily in the intestine and secreted in plasma.
Similitudes de séquence
Belongs to the apolipoprotein A1/A4/E family.
Modification post-traductionnelle
Phosphorylation sites are present in the extracellular medium.
Localisation cellulaire
Secreted.
