APLP1 est un gène codé par le symbole APLP1. D'autres noms incluent: Amyloid-like protein 1; APLP. APLP1 a une masse de 72.18kDa et une longueur d'acide aminé de 650.
Nous proposons 6 des anticorps contre APLP1, élevé dans Lapin, qui sont appropriés pour le WB, IHC et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
Résumé Entrez
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
Spécificité tissulaire
Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD).
Similitudes de séquence
Belongs to the APP family.
Modification post-traductionnelle
Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3 (By similarity).
Localisation cellulaire
Cell membrane.
