Apg12 est un gène codé par le symbole ATG12. D'autres noms incluent: Ubiquitin-like protein ATG12; Autophagy-related protein 12-like; ATG12L. Apg12 a une masse de 15.11kDa et une longueur d'acide aminé de 140.
Nous proposons 11 des anticorps contre Apg12, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC et ICC/IF avec des échantillons dérivés de Humain, Souris, Rat, Singe et Canin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes.
Résumé Entrez
Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998
Spécificité tissulaire
Ubiquitous.
Similitudes de séquence
Belongs to the ATG12 family.
Modification post-traductionnelle
Acetylated by EP300.
Localisation cellulaire
Cytoplasm. Preautophagosomal structure membrane.
TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.
