Annexin VI est un gène codé par le symbole ANXA6. D'autres noms incluent: Annexin A6; 67 kDa calelectrin; Annexin-6; Calphobindin-II; CPB-II; Chromobindin-20; Lipocortin VI; Protein III; p68; p70; ANXA6; ANX6. Annexin VI a une masse de 75.87kDa et une longueur d'acide aminé de 673.
Nous proposons 14 des anticorps contre Annexin VI, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris, Rat et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
Résumé Entrez
Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described.
Similitudes de séquence
Belongs to the annexin family.
Modification post-traductionnelle
Phosphorylated in response to growth factor stimulation.
Localisation cellulaire
Cytoplasm. Melanosome.
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
