alpha 2 Macroglobulin est un gène codé par le symbole A2M. D'autres noms incluent: Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; A2M; CPAMD5. alpha 2 Macroglobulin a une masse de 163.29kDa et une longueur d'acide aminé de 1474.
Nous proposons 36 des anticorps contre alpha 2 Macroglobulin, élevé dans Lapin, Souris, Chèvre, Rat et Sheep, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et RIA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Résumé Entrez
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.
Spécificité tissulaire
Secreted in plasma.
Similitudes de séquence
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
Localisation cellulaire
Secreted.
