alpha 1 Catenin est un gène codé par le symbole CTNNA1. D'autres noms incluent: Catenin alpha-1; Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13; CTNNA1. alpha 1 Catenin a une masse de 100.07kDa, une longueur d'acide aminé de 906, et est impliqué dans Macular dystrophy, patterned, 2.
Nous proposons 8 des anticorps contre alpha 1 Catenin, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat et Poulet.
Informations sur les Gènes et les Protéines
Résumé UniProt
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
Résumé Entrez
This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy.
Spécificité tissulaire
Expressed ubiquitously in normal tissues.
Implication dans la maladie
Macular dystrophy, patterned, 2: A form of retinal patterned dystrophy, a heterogeneous group of macular disorders caused by abnormal accumulation of lipofuscin in the retinal pigment epithelium. Lipofuscin distribution can show various shapes that define different types of macular dystrophy, including reticular (fishnet-like) dystrophy, macroreticular (spider-shaped) dystrophy and butterfly-shaped pigment dystrophy. MDPT2 is an autosomal dominant form characterized by bilateral accumulation of pigment in the macular area that resembles the wings of a butterfly.
Similitudes de séquence
Belongs to the vinculin/alpha-catenin family.
Modification post-traductionnelle
Sumoylated.
Localisation cellulaire
Cytoplasm > Cytoskeleton. Cell junction > Adherens junction. Cell membrane. Cell junction.
Found at cell-cell boundaries and probably at cell-matrix boundaries.
