alpha 1 Antichymotrypsin est un gène codé par le symbole SERPINA3. D'autres noms incluent: Alpha-1-antichymotrypsin; ACT; Cell growth-inhibiting gene 24/25 protein; Serpin A3; SERPINA3; AACT. alpha 1 Antichymotrypsin a une masse de 47.65kDa et une longueur d'acide aminé de 423.
Nous proposons 33 des anticorps contre alpha 1 Antichymotrypsin, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Résumé Entrez
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.
Spécificité tissulaire
Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
Similitudes de séquence
Belongs to the serpin family.
Modification post-traductionnelle
N- and O-glycosylated.
Localisation cellulaire
Secreted.
