AICDA est un gène codé par le symbole AICDA. D'autres noms incluent: Single-stranded DNA cytosine deaminase; Activation-induced cytidine deaminase; AID; Cytidine aminohydrolase. AICDA a une masse de 23.95kDa, une longueur d'acide aminé de 198, et est impliqué dans Immunodeficiency with hyper-IgM 2.
Nous proposons 10 des anticorps contre AICDA, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894).
Résumé Entrez
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2).
Spécificité tissulaire
Strongly expressed in lymph nodes and tonsils.
Implication dans la maladie
Immunodeficiency with hyper-IgM 2: A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.
Similitudes de séquence
Belongs to the cytidine and deoxycytidylate deaminase family.
Modification post-traductionnelle
Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity.
Localisation cellulaire
Nucleus. Cytoplasm.
Predominantly cytoplasmic (PubMed:21385873). In the presence of MCM3AP/GANP, relocalizes to the nucleus (By similarity).
