ADK est un gène codé par le symbole ADK. D'autres noms incluent: Adenosine kinase; AK; Adenosine 5'-phosphotransferase. ADK a une masse de 40.55kDa, une longueur d'acide aminé de 362, et est impliqué dans Hypermethioninemia due to adenosine kinase deficiency.
Nous proposons 7 des anticorps contre ADK, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Résumé Entrez
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Widely expressed. Highest level in placenta, liver, muscle and kidney.
Implication dans la maladie
Hypermethioninemia due to adenosine kinase deficiency: A metabolic disorder characterized by global developmental delay, early-onset seizures, mild dysmorphic features, and characteristic biochemical anomalies, including persistent hypermethioninemia with increased levels of S-adenosylmethionine and S-adenosylhomocysteine. Homocysteine levels are typically normal.
Similitudes de séquence
Belongs to the carbohydrate kinase PfkB family.
Localisation cellulaire
Nucleus.
