Adenosine Receptor A2a est un gène codé par le symbole ADORA2A. D'autres noms incluent: ADORA2A; ADORA2. Adenosine Receptor A2a a une masse de 44.71kDa et une longueur d'acide aminé de 412.
Nous proposons 12 des anticorps contre Adenosine Receptor A2a, élevé dans Lapin, Chèvre et Human, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
Résumé Entrez
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.
Similitudes de séquence
Belongs to the G-protein coupled receptor 1 family.
Modification post-traductionnelle
Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface.
Localisation cellulaire
Cell membrane.
Colocalizes with GAS2L2 at neuronal processes.
