ADCY8 est un gène codé par le symbole ADCY8. D'autres noms incluent: Adenylate cyclase type 8; ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; AC8; Ca(2+)/calmodulin-activated adenylyl cyclase. ADCY8 a une masse de 140.12kDa et une longueur d'acide aminé de 1251.
Nous proposons 6 des anticorps contre ADCY8, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells.
Résumé Entrez
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase
Spécificité tissulaire
Detected in brain cortex (PubMed:1715695). Expressed in islet (PubMed:25403481).
Similitudes de séquence
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Modification post-traductionnelle
Phosphorylated by PKA; mediates inhibition of adenylate cyclase activity at membrane raft; does not influence either CALM1 or PPP2CA interaction with ADCY8.
Localisation cellulaire
Cell membrane. Basolateral cell membrane. Apical cell membrane. Cell junction > Synapse. Cell projection > Dendrite. Cell projection > Axon. Cell junction > Synapse > Presynaptic cell membrane. Cell junction > Synapse > Postsynaptic density. Membrane raft. Membrane > Coated pit. Cytoplasmic vesicle > Clathrin-coated vesicle membrane. Membrane > Caveola.
Localized to dendritic arbors (By similarity). Monomeric N-glycosylated species localizes in membrane raft. In contrast, monomeric unglycosylated forms are enriched in clathrin-coated pits and vesicles. Dimers are also localized outside of membrane rafts. Membrane raft localization and integrity is indispensable for CCE-stimulated adenylate cyclase activity (By similarity).
