ADCY3 est un gène codé par le symbole ADCY3. D'autres noms incluent: Adenylate cyclase type 3; ATP pyrophosphate-lyase 3; Adenylate cyclase type III; AC-III; Adenylate cyclase, olfactive type; Adenylyl cyclase 3; AC3; KIAA0511. ADCY3 a une masse de 128.96kDa, une longueur d'acide aminé de 1144, et est impliqué dans Obesity.
Nous proposons 7 des anticorps contre ADCY3, élevé dans Lapin et Poulet, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris, Rat et Canin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
Résumé Entrez
This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle (PubMed:9920776). Detected in testis (PubMed:15705663).
Implication dans la maladie
Obesity: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Similitudes de séquence
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Modification post-traductionnelle
Sumoylated. Sumoylation is required for targeting ot olfactory cilia.
Localisation cellulaire
Cell membrane. Cytoplasm. Cell projection > Cilium. Golgi apparatus.
Also detected in the cytoplasm, close to lipid droplets.
