5T4 est un gène codé par le symbole TPBG. Les alias courants comprennent: Trophoblast glycoprotein oncofetal antigen oncofetal trophoblast glycoprotein oncotrophoblast glycoprotein; M6P1; Wnt-activated inhibitory factor 1; WAIF1; TPBG. 5T4 a une masse de 46.03kDa et une longueur d'acide aminé de 420.
Nous proposons 11 des anticorps contre 5T4, élevé dans Lapin, Souris et Human, qui sont appropriés pour le WB, ELISA et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
Résumé Entrez
This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein.
Spécificité tissulaire
Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
Modification post-traductionnelle
Highly glycosylated.
Localisation cellulaire
Cell membrane.
