5 Lipoxygenase est un gène codé par le symbole ALOX5. Les alias courants comprennent: Arachidonate 5-lipoxygenase; 5-LO; ALOX5; LOG5. 5 Lipoxygenase a une masse de 77.98kDa et une longueur d'acide aminé de 674.
Nous proposons 8 des anticorps contre 5 Lipoxygenase, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Résumé Entrez
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Similitudes de séquence
Belongs to the lipoxygenase family.
Modification post-traductionnelle
Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus.
Localisation cellulaire
Cytoplasm. Nucleus matrix. Nucleus membrane.
Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.
