14-3-3 epsilon est un gène codé par le symbole YWHAE. Les alias courants comprennent: 14-3-3 protein epsilon; 14-3-3E; YWHAE. 14-3-3 epsilon a une masse de 29.17kDa et une longueur d'acide aminé de 255.
Nous proposons 6 des anticorps contre 14-3-3 epsilon, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326).
Résumé Entrez
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.
Similitudes de séquence
Belongs to the 14-3-3 family.
Localisation cellulaire
Nucleus. Cytoplasm. Melanosome.
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
