Tissue Factor est un gène codé par le symbole F3. Il est également connu sous le nom de: TF; Coagulation factor III; Thromboplastin; F3. Tissue Factor a une masse de 33.07kDa et une longueur d'acide aminé de 295.
Nous proposons 15 Tissue Factor kits ELISA pour la détection qualitative ou quantitative de Tissue Factor à partir d'échantillons Humain, Souris, Rat, Porcin, Lapin et Cheval.
Informations sur les Gènes et les Protéines
Résumé UniProt
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Résumé Entrez
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.
Spécificité tissulaire
Lung, placenta and pancreas.
Similitudes de séquence
Belongs to the tissue factor family.
Localisation cellulaire
Membrane.
