TSLP est un gène codé par le symbole TSLP. Il est également connu sous le nom de Thymic stromal lymphopoietin. TSLP a une masse de 18.14kDa et une longueur d'acide aminé de 159.
Nous proposons 17 TSLP kits ELISA pour la détection qualitative ou quantitative de TSLP à partir d'échantillons Humain, Souris, Rat, Porcin, Singe et Canin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
Résumé Entrez
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.
Spécificité tissulaire
Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands. It is secreted into saliva.
Localisation cellulaire
Secreted.
