TIMP1 est un gène codé par le symbole TIMP1. Il est également connu sous le nom de: Metalloproteinase inhibitor 1; Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 1; TIMP-1; CLGI; TIMP. TIMP1 a une masse de 23.17kDa et une longueur d'acide aminé de 207.
Nous proposons 22 TIMP1 kits ELISA pour la détection qualitative ou quantitative de TIMP1 à partir d'échantillons Humain, Souris, Rat, Bovin, Porcin, Lapin, Singe, Mouton, Canin, Cochon d'Inde et Cheval.
Informations sur les Gènes et les Protéines
Résumé UniProt
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
Résumé Entrez
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
Spécificité tissulaire
Detected in rheumatoid synovial fluid (at protein level).
Similitudes de séquence
Belongs to the protease inhibitor I35 (TIMP) family.
Modification post-traductionnelle
The activity of TIMP1 is dependent on the presence of disulfide bonds.
Localisation cellulaire
Secreted.