BMP7 est un gène codé par le symbole BMP7. D'autres noms incluent: Bone morphogenetic protein 7; BMP-7; Osteogenic protein 1; OP-1; OP1. BMP7 a une masse de 49.31kDa et une longueur d'acide aminé de 431.
Nous proposons 13 BMP7 kits ELISA pour la détection qualitative ou quantitative de BMP7 à partir d'échantillons Humain, Souris, Rat et Bovin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Promotes brown adipocyte differentiation by P38 MAPK pathway-mediated activation of target genes, including members of the SOX family of transcription factors (PubMed:27923061).
Résumé Entrez
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients.
Spécificité tissulaire
Expressed in the kidney and bladder. Lower levels seen in the brain.
Similitudes de séquence
Belongs to the TGF-beta family.
Modification post-traductionnelle
Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms.
Localisation cellulaire
Secreted.
