Macrophage Inflammatory Protein 1 beta est un gène codé par le symbole CCL4. Communément appelé aussi: C-C motif chemokine 4; G-26 T-lymphocyte-secreted protein; HC21; Lymphocyte activation gene 1 protein; LAG-1; MIP-1-beta(1-69); Macrophage inflammatory protein 1-beta; MIP-1-beta; PAT 744; Protein H400; SIS-gamma; Small-inducible cytokine A4; T-cell activation protein 2; ACT-2; CCL4; LAG1; MIP1B; SCYA4. Macrophage Inflammatory Protein 1 beta a une masse de 10.21kDa et une longueur d'acide aminé de 92.
Nous proposons 3 Macrophage Inflammatory Protein 1 beta kits ELISA pour la détection qualitative ou quantitative de Macrophage Inflammatory Protein 1 beta à partir d'échantillons Humain, Souris et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Résumé Entrez
This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. Alternative splicing of this gene results in multiple transcript variants.
Similitudes de séquence
Belongs to the intercrine beta (chemokine CC) family.
Modification post-traductionnelle
N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.
Localisation cellulaire
Secreted.
