FLAP est un gène codé par le symbole ALOX5AP. D'autres noms incluent: Arachidonate 5-lipoxygenase-activating protein; MK-886-binding protein; ALOX5AP. FLAP a une masse de 18.16kDa, une longueur d'acide aminé de 161, et est impliqué dans Ischemic stroke.
Nous proposons 2 FLAP kits ELISA pour la détection qualitative ou quantitative de FLAP à partir d'échantillons Humain et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
Résumé Entrez
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Implication dans la maladie
Ischemic stroke: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Similitudes de séquence
Belongs to the MAPEG family.
Localisation cellulaire
Nucleus membrane. Endoplasmic reticulum membrane.
