CEACAM5 est un gène codé par le symbole CEACAM5. D'autres noms incluent: Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100. CEACAM5 a une masse de 76.8kDa et une longueur d'acide aminé de 702.
Nous proposons 5 CEACAM5 kits ELISA pour la détection qualitative ou quantitative de CEACAM5 à partir d'échantillons Humain et Souris.
Informations sur les Gènes et les Protéines
Résumé UniProt
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
Résumé Entrez
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.
Spécificité tissulaire
Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Similitudes de séquence
Belongs to the immunoglobulin superfamily. CEA family.
Modification post-traductionnelle
Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
Localisation cellulaire
Cell membrane. Apical cell membrane. Cell surface.
Localized to the apical glycocalyx surface.
