Essais APC

5 produits

APC est un gène codé par le symbole APC. D'autres noms incluent: Adenomatous polyposis coli protein; Protein Deleted in polyposis 2.5; DP2.5. APC a une masse de 311.65kDa, une longueur d'acide aminé de 2843, et est impliqué dans les maladies: Familial adenomatous polyposis; Hereditary desmoid disease; Medulloblastoma; Gastric cancer; Hepatocellular carcinoma.

Nous proposons 5 APC kits ELISA pour la détection qualitative ou quantitative de APC à partir d'échantillons Humain, Souris et Rat.

Informations sur les Gènes et les Protéines

Résumé UniProt
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Résumé Entrez
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Spécificité tissulaire
Expressed in a variety of tissues: brain, small intestine, colon, thymus, skeletal muscle, heart, prostate, lung, spleen, ovary, testis kidney, placenta, blood and liver (PubMed:21643010, PubMed:27217144). Isoform 1A: Very strongly expressed in brain but has relatively low expression levels in other tissues (PubMed:19527921, PubMed:21643010, PubMed:27217144). Isoform 1B: Predominant form in all tissues except for brain, including gastric mucosa and blood (PubMed:19527921, PubMed:21643010, PubMed:27217144).
Implication dans la maladie
Familial adenomatous polyposis: A cancer predisposition syndrome characterized by adenomatous polyps of the colon and rectum, but also of upper gastrointestinal tract (ampullary, duodenal and gastric adenomas). This is a viciously premalignant disease with one or more polyps progressing through dysplasia to malignancy in untreated gene carriers with a median age at diagnosis of 40 years.

Hereditary desmoid disease: Autosomal dominant trait with 100% penetrance and possible variable expression among affected relatives. HDD patients show multifocal fibromatosis of the paraspinal muscles, breast, occiput, arms, lower ribs, abdominal wall, and mesentery. Desmoid tumors appears also as a complication of familial adenomatous polyposis.

Medulloblastoma: Malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children.

Gastric cancer: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.

Hepatocellular carcinoma: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.
Similitudes de séquence
Belongs to the adenomatous polyposis coli (APC) family.
Modification post-traductionnelle
Phosphorylated by GSK3B.
Localisation cellulaire
Cell junction > Adherens junction. Cytoplasm > Cytoskeleton. Cell projection > Lamellipodium. Cell projection > Ruffle membrane. Cytoplasm. Cell membrane.

Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment (PubMed:19151759). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854).
Liens de base de données
Standard Curve - Human APC ELISA Kit (A79114) - Antibodies.com
Standard Curve - Mouse APC ELISA Kit (A312854) - Antibodies.com
Voir le roduitELISA de 90 minutes
Standard Curve - Human APC ELISA Kit (A311964) - Antibodies.com
Voir le roduitELISA de 90 minutes
Western Blot - APC Cell Based ELISA Kit (CB5045) - Antibodies.com
(4)
Western Blot - APC (phospho Ser2054) Cell Based ELISA Kit (CBP1319) - Antibodies.com
(4)

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