Angiotensinogen est un gène codé par le symbole AGT. D'autres noms incluent: Serpin A8; AGT; SERPINA8. Angiotensinogen a une masse de 53.15kDa, une longueur d'acide aminé de 485, et est impliqué dans les maladies: Essential hypertension; Renal tubular dysgenesis.
Nous proposons 11 Angiotensinogen kits ELISA pour la détection qualitative ou quantitative de Angiotensinogen à partir d'échantillons Humain, Souris, Rat, Porcin et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
Résumé Entrez
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
Spécificité tissulaire
Expressed by the liver and secreted in plasma.
Implication dans la maladie
Essential hypertension: A condition in which blood pressure is consistently higher than normal with no identifiable cause.
Renal tubular dysgenesis: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Similitudes de séquence
Belongs to the serpin family.
Modification post-traductionnelle
Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.
Localisation cellulaire
Secreted.