Anti-PON1 Anticorps [PON1/1351] (A315527)

Anti-PON1 Antibody [PON1/1351]

Mouse monoclonal [PON1/1351] antibody to PON1.

Paroxon is an organophosphorus anticholinesterase compound, used topically in the treatment of glaucoma. It is produced in vivo in mammals by microsomal oxidation of the insecticide parathion. Parathion is inert until transformed to paroxon. Paroxonase or PON is an arylesterase that is capable of hydrolyzing paroxon to produce p-nitrophenol. PONs are nonspecific and their classification is based not only on substrate specificity but also on tissue distribution, inhibition properties and physicochemical characteristics such as electrophoretic mobility and molecular weight. In contrast to PON1, which is expressed mainly in the liver, PON2 is expressed in a variety of mouse tissues, including the pancreas. PON3 is a associated with the high density lipoprotein fraction of serum. The genes which encode PON1-3 are physically linked and map to human chromosome 7q21.3.

IHC-P

Human liver.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-200) of human PON1 protein. The exact sequence is proprietary.

Mouse

Monoclonal

PON1/1351

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

43 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

A esterase 1, A-esterase 1, Aromatic esterase 1, Arylesterase 1, Arylesterase B type, ESA, Esterase A, K 45, K-45, MVCD5, Paraoxonase, Paraoxonase 1, Paraoxonase B type, Paraoxonase, plasma, Paraoxonase1, PON, PON 1, PON1_HUMAN, Serum aryldiakylphosphatase, Serum aryldialkylphosphatase 1, Serum paraoxonase/arylesterase 1