This antibody recognises DNA-directed RNA polymerase, mitochondrial, also known as MtRPOL, MTRNAP, and APOLMT. POLRMT is a mitochondrial RNA polymerase absolutely required for expression of mitochondrial genes, and required for replication of the mitochondrial genome (Kühl et al. 2016). Evidence does not support the existence of a nuclear isoform of POLRMT, suggesting that its role is exclusively mitochondrial (Kühl et al. 2014).
Applications
WB, IP
Recommander des dilutions
IP: 1:50 - 1:100, WB: 1:500 - 1:2,000
Reactivité
Human
Immunogène
Recombinant fusion protein containing a sequence corresponding to amino acids 42-230 of human POLRMT (NP_005026.3).
Supplied in Phosphate Buffered Saline with 0.05% ProClin 300 and 50% Glycerol.
Stockage
Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.
Notes générales
Rabbit anti POLRMT antibody recognizes DNA-directed RNA polymerase, mitochondrial, also known as MtRPOL, MTRNAP, and APOLMT. POLRMT is a mitochondrial RNA polymerase absolutely required for expression of mitochondrial genes, and required for replication of the mitochondrial genome (Kühl et al. 2016). Evidence does not support the existence of a nuclear isoform of POLRMT, suggesting that its role is exclusively mitochondrial (Kühl et al. 2014).
