Anti-PMS1 Anticorps [PCRP-PMS1-2E11] (A277752)

Anticorps monoclonal [PCRP-PMS1-2E11] de souris contre PMS1 pour ELISA, IP, Flow Cytometry et IF.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-PMS1 Antibody [PCRP-PMS1-2E11]
Description du produit
Mouse monoclonal [PCRP-PMS1-2E11] antibody to PMS1.
Spécificité
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.
Applications
ELISA, IP, Flow Cytometry, IF
Recommander des dilutions
Flow Cytometry: 1-2 µg/million cells, IP: 1-2µg / 100-500µg proteins, IF: 1-2 µg/ml
Reactivité
Human
Immunogène
Recombinant full-length human PMS1 protein.
Hôte
Mouse
Clonalité
Monoclonal
Clone
PCRP-PMS1-2E11
Isotype
IgG1
Conjuguer

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Masse moléculaire
105.8 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Notes générales
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-PMS1 Antibody [PCRP-PMS1-2E11] - BSA and Azide free (A278340).
Synonymes
DNA mismatch repair protein PMS1, FLJ98259, HNPCC3, hPMS1, Human homolog of yeast mutL, Mismatch repair gene PMSL1, PMS1 postmeiotic segregation increased 1, PMS1 postmeiotic segregation increased 1 (S. cerevisiae), PMS1 protein homolog 1, PMS1_HUMAN, PMSL1, Rhabdomyosarcoma antigen MU RMS 40.10B, Rhabdomyosarcoma antigen MU RMS 40.10E
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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