Anti-PI 3 Kinase p85 beta Anticorps [PIK3R2/292] (A277748)

Name: Anti-PI 3 Kinase p85 beta Antibody [PIK3R2/292]
Brand: Antibodies.com
SKU: A277748
Price: 525.0 USD
Availability: InStock

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$525

Anticorps monoclonal [PIK3R2/292] de souris contre PI 3 Kinase p85 beta pour IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Carrier Free and Preservative Free

Livraison

Frais de livraison

$40

Date de livraison

Livraison sous 4-6 jours ouvrables.

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Téléphone

+1 (314) 370-6046

E-mail

orders@antibodies.com

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Mots clés :

Anticorps Monospécifique

Spécifications

Nom du produit

Anti-PI 3 Kinase p85 beta Antibody [PIK3R2/292]

Description du produit

Mouse monoclonal [PIK3R2/292] antibody to PI 3 Kinase p85 beta.

Spécificité

Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85Î± and p85Î²), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110Î± and p110Î² interact with p85Î±, and p110Î± has also been shown to interact with p85Î² in vitro. p110 L expression is restricted to white blood cells. It has been shown to bind p85Î± and p85Î², but it apparently does not phosphorylate these subunits. p110 L seems to have the capacity to autophosphorylate. p110Î³ does not interact with the p85 subunits. It has been shown to be activated by Î± and Î²Î³ heterotrimeric G proteins.

Applications

IHC-P

Recommander des dilutions

IHC-P: 1-2 µg/ml

Reactivité

Human

Immunogène

Recombinant fragment, around amino acids 520-720, of human PIK3R2 protein. The exact sequence is proprietary.

Hôte

Mouse

Clonalité

Monoclonal

Clone

PIK3R2/292

Isotype

IgG2b

Chaînes légères

kappa

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Masse moléculaire

85 kDa

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes générales

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-PI 3 Kinase p85 beta Antibody [PIK3R2/292] - BSA and Azide free (A278336).

Synonymes

p85, p85 beta, P85B, P85B_HUMAN, Phosphatidylinositol 3 kinase, Phosphatidylinositol 3 kinase regulatory beta subunit, Phosphatidylinositol 3 kinase regulatory subunit beta, Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2, Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2 (p85 beta), Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta, Phosphatidylinositol 3-kinase regulatory subunit beta, Phosphoinositide 3 kinase regulatory subunit 2, Phosphoinositide 3 kinase regulatory subunit 2 (beta), Phosphoinositide 3 kinase regulatory subunit polypeptide 2, Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta), Phosphoinositide 3 kinase, regulatory subunit 2 (beta), Phosphoinositide 3 kinase, regulatory subunit 2 (p85 beta), PI3 kinase p85 beta subunit, PI3 kinase p85 subunit beta, PI3-kinase regulatory subunit beta, PI3-kinase subunit p85-beta, PI3K, PI3K regulatory subunit beta, PIK3R 2, PIK3R2, PtdIns 3 kinase p85 beta, PtdIns-3-kinase regulatory subunit beta, PtdIns-3-kinase regulatory subunit p85-beta

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

Images (3)

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Figure 1: Immunohistochemistry - Anti-PI 3 Kinase p85 beta Antibody [PIK3R2/292] (A277748)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human spleen tissue using Anti-PI 3 Kinase p85 beta Antibody [PIK3R2/292].

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Figure 2: Immunohistochemistry - Anti-PI 3 Kinase p85 beta Antibody [PIK3R2/292] (A277748)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human bladder carcinoma tissue using Anti-PI 3 Kinase p85 beta Antibody [PIK3R2/292]. Inset: PBS instead of the primary antibody. Secondary antibody negative control.

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Figure 3: Anti-PI 3 Kinase p85 beta Antibody [PIK3R2/292] (A277748)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-PI 3 Kinase p85 beta Antibody [PIK3R2/292]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.