Recombinant Anti-PAX2 Anticorps [PAX2/8671R] (A315464)

Anti-PAX2 Antibody [PAX2/8671R]

Recombinant rabbit monoclonal [PAX2/8671R] antibody to PAX2.

Recognizes a protein of 42kDa, which is identified as PAX2. It is a member of the paired box family of transcription factors, which is required for development and proliferation of the kidney, brain, and mullerian organs. PAX2 genes contain a highly conserved DNA sequence within the paired box region, which encodes a DNA-binding domain, enabling PAX proteins to bind the promoters of specific genes to transcriptionally regulate their expression. PAX2 is specifically expressed in the developing central nervous system, eye, ear, and urogenital tract, and is essential for the development of these organs. In normal adult tissues PAX2 was mainly detected in the urogenital system, including kidney, ureteric epithelium, fallopian tube epithelium, ovary and uterus. In tumors, PAX2 has been detected in renal cell carcinomas, Wilms tumors, nephrogenic adenomas and papillary serous carcinoma of the ovary. PAX2 has been used as a marker for the identification of renal cell carcinoma and ovarian carcinoma by immunohistochemistry.

IHC-P

NAMALWA cells. Human fetal kidney, renal cell carcinoma (RCC) or ovarian carcinoma.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 223-354) of human PAX2 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

PAX2/8671R

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

42 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

FSGS7, Paired box 2, Paired box gene 2, paired box homeotic gene 2, paired box protein 2, Paired box protein Pax 2, Paired box protein Pax-2, Paired box protein Pax2, PAPRS, Pax 2