Recombinant Anti-p21 Anticorps [CIP1/4377R] (A248091)

Name: Anti-p21 Antibody [CIP1/4377R]
Brand: Antibodies.com
SKU: A248091
Price: 525.0 USD
Availability: InStock

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$525

Anticorps monoclonal [CIP1/4377R] de lapin contre p21 pour IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Carrier Free and Preservative Free

Livraison

Frais de livraison

$40

Date de livraison

Livraison sous 4-6 jours ouvrables.

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Téléphone

+1 (314) 370-6046

E-mail

orders@antibodies.com

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Mots clés :

Anticorps Recombinant

Spécifications

Nom du produit

Anti-p21 Antibody [CIP1/4377R]

Description du produit

Recombinant rabbit monoclonal [CIP1/4377R] antibody to p21.

Spécificité

This antibody recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This antibody is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).

Applications

IHC-P

Recommander des dilutions

IHC-P: 1-2 µg/ml

Reactivité

Human

Immunogène

Synthetic peptide corresponding to amino acids 1-100 of p21 protein.

Hôte

Rabbit

Clonalité

Monoclonal

Clone

CIP1/4377R

Isotype

IgG

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Masse moléculaire

21 kDa

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes générales

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-p21 Antibody [CIP1/4377R] - BSA and Azide free (A251274).

Synonymes

CAP20, CDK-interacting protein 1, CDKI, CDKN1, Cdkn1a, CDN1A_HUMAN, CIP1, Cyclin Dependent Kinase Inhibitor 1A, Cyclin-dependent kinase inhibitor 1, Cyclin-dependent kinase inhibitor 1A (P21), Cyclin-dependent kinase inhibitor 1A (p21, Cip1), DNA Synthesis Inhibitor, MDA-6, MDA6, Melanoma differentiation-associated protein, Melanoma differentiation-associated protein 6, P21 protein, p21CIP1, p21Cip1/Waf1, p21WAF, PIC1, SDI1, SLC12A9, WAF1, Wild type p53 activated fragment 1, Wild type p53 activated fragment 1 (WAF1), Wildtype p53-activated fragment 1

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

Images (3)

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Figure 1: Immunohistochemistry - Anti-p21 Antibody [CIP1/4377R] (A248091)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon carcinoma using Anti-p21 Antibody [CIP1/4377R].

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Figure 2: Immunohistochemistry - Anti-p21 Antibody [CIP1/4377R] (A248091)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human lungcarcinoma using Anti-p21 Antibody [CIP1/4377R].

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Figure 3: Anti-p21 Antibody [CIP1/4377R] (A248091)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-p21 Antibody [CIP1/4377R]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.