Anti-NRF1 Anticorps [NRF1/2608] (A252712)

Name: Anti-NRF1 Antibody [NRF1/2608] - BSA and Azide free
Brand: Antibodies.com
SKU: A252712
Price: 525.0 USD
Availability: InStock

Cliquez pour ouvrir le point de vue élargi

$525

Anticorps monoclonal [NRF1/2608] de souris contre NRF1 pour IHC-P.

Qualité 100 % Garantie

Garantie de Correspondance des Prix

Alternative Formats and ConjugatesAlternative Formats

Unconjugated

Livraison

Frais de livraison

$40

Date de livraison

Livraison sous 4-6 jours ouvrables.

Nous ContacterContact

Téléphone

+1 (314) 370-6046

E-mail

orders@antibodies.com

Garanties

Qualité 100 % Garantie

Garantie de Correspondance des Prix

Mots clés :

Anticorps Monospécifique

Spécifications

Nom du produit

Anti-NRF1 Antibody [NRF1/2608] - BSA and Azide free

Description du produit

Mouse monoclonal [NRF1/2608] antibody to NRF1.

Spécificité

The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK, and it regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (MAREs). A family of NF-E2 related proteins, which are collectively known as the Cap 'n' collar (CNC) family and include Nrf1 (also designated TCF11), Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind MARE sequences. The Nrf proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, JunB and JunD) to activate gene expression, specifically the detoxifying enzyme, NQO1. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1. Nrf3 is highly expressed in placenta, B cells and monocytes.

Applications

IHC-P

Recommander des dilutions

IHC-P: 1-2 µg/ml

Reactivité

Human

Immunogène

Recombinant full-length human NRF1 protein.

Hôte

Mouse

Clonalité

Monoclonal

Clone

NRF1/2608

Isotype

IgG1

Chaînes légères

kappa

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

1 mg/ml

Masse moléculaire

30 kDa (bZIP region) / 65-120 kDa (glycosylated)

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes générales

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-NRF1 Antibody [NRF1/2608] (A249532).

Synonymes

alpha pal, alpha palindromic binding protein, Alpha palindromic-binding protein, Alpha-pal, locus control region factor 1, NFE2 related factor 1, NRF-1, NRF1_HUMAN, Nuclear respiratory factor 1

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

Images (3)

Cliquez pour ouvrir le point de vue élargi

Figure 1: Immunohistochemistry - Anti-NRF1 Antibody [NRF1/2608] - BSA and Azide free (A252712)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon carcinoma using Anti-NRF1 Antibody [NRF1/2608].

Cliquez pour ouvrir le point de vue élargi

Figure 2: SDS-PAGE - Anti-NRF1 Antibody [NRF1/2608] - BSA and Azide free (A252712)

SDS-PAGE analysis of Anti-NRF1 Antibody [NRF1/2608] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

Cliquez pour ouvrir le point de vue élargi

Figure 3: Anti-NRF1 Antibody [NRF1/2608] - BSA and Azide free (A252712)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-NRF1 Antibody [NRF1/2608]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.